Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers
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چکیده
منابع مشابه
Comparison of the Pharmacokinetic Properties of Hemoglobin-Based Oxygen Carriers
Hemoglobin (Hb) is an ideal material for use in the development of an oxygen carrier in view of its innate biological properties. However, the vascular retention of free Hb is too short to permit a full therapeutic effect because Hb is rapidly cleared from the kidney via glomerular filtration or from the liver via the haptogloblin-CD 163 pathway when free Hb is administered in the blood circula...
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For many decades, Hemoglobin-based oxygen carriers (HBOCs) have been central in the development of resuscitation agents that might provide oxygen delivery in addition to simple volume expansion. Since 80% of the world population lives in areas where fresh blood products are not available, the application of these new solutions may prove to be highly beneficial (Kim and Greenburg 2006). Many imp...
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ژورنال
عنوان ژورنال: Journal of Functional Biomaterials
سال: 2017
ISSN: 2079-4983
DOI: 10.3390/jfb8010011